Transplantation immunology
نویسنده
چکیده
This Special Focus on Transplantation Immunology issue of Chimerism features papers focusing on the role of chimerism in transplantation immunology. The field of immunologic tolerance, which owes its origins to an experiment of nature resulting in hematopoetic mixed chimerism, is the subject of our featured Forum article—a debate between Jeff Mold and Colin Anderson on the implications for tolerance of the layered development of the human immune system (p. 62). Jeff argues that different species (e.g., mice vs. humans) have different solutions to achieve tolerance, with a preponderance of Treg in fetal life being critical for primates, while Colin considers the primary rules for tolerance are instead conserved and argues for the primacy of central tolerance. The impact of fetal chimerism resulting from pregnancy on the outcome of organ transplantation in women of childbearing age is the subject of a Cutting Edge View Transplantation immunology
منابع مشابه
Prediction of Rejection in Renal Transplantation by Immune Parameters
Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients. Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) wer...
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Microchimerism and Renal Transplantation: Doubt Still Persists
Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...
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